ESV Reformation Study Bible – Isa 66:3
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Isa 66:3

66:3 kills a man. This may be an allusion to child sacrifice (cf. Jer. 7:31; Ezek. 23:39).

breaks a dog’s neck. Only certain animals were prescribed for sacrifice. The dog was not even permitted for food (56:10 note; Lev. 11:26).

pig’s blood. See 65:4.