ESV Reformation Study Bible – Isa 65:20
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Isa 65:20

65:20 infant . . . old man. Premature death of infants or persons in mid-career can provoke the thought that life is meaningless. Such early death, as also the transfer of one person’s reward to another person who did not earn it (v. 22), is part of God’s judgment on sin. God promises to remove this curse from His people (Amos 5:11 note).